Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | USP19 | O94966 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246426 | 0.90 | GAA (0.41) | SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL21246362 | 0.88 | LMNA (0.46) | SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL21246428 | 0.88 | LMNA (0.48) | SMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL21246424 | 0.87 | P2RX7 (0.40) | — | |
| SCHEMBL21246366 | 0.86 | THRB (0.47) | SMN1; SMN2KMT2ALMNAALDH1A1CYP3A4 | |
| SCHEMBL21246359 | 0.86 | SLC1A2 (0.51) | SLC1A2KMT2ALMNACYP3A4 | |
| SCHEMBL21246365 | 0.84 | TSHR (0.46) | KMT2AALDH1A1CYP3A4 | |
| SCHEMBL21246364 | 0.84 | CYP3A4 (0.41) | LMNACYP3A4 | |
| SCHEMBL21246349 | 0.83 | USP19 (0.33) | USP19 | |
| SCHEMBL21246340 | 0.83 | SLC1A2 (0.44) | SLC1A2SMN1; SMN2KMT2AUSP19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152688-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2019-08-08 | — | — | WO | disclosed |