Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 5/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29490274 | 1.00 | KCNH2 (0.43) | KCNH2GRM5PGK1CHRNA7RORC | |
| SCHEMBL11236538 | 0.92 | GRM5 (0.46) | KCNH2GRM5PGK1CHRNA7RORC | |
| SCHEMBL11246729 | 0.90 | GRM5 (0.49) | KCNH2GRM5CHRNA7RORCCYP1A2 | |
| SCHEMBL9152622 | 0.90 | GRM5 (0.49) | KCNH2GRM5CHRNA7RORCCYP1A2 | |
| SCHEMBL31071600 | 0.87 | KCNH2 (0.38) | KCNH2GRM5CHRNA7 | |
| SCHEMBL21723366 | 0.87 | KCNH2 (0.38) | KCNH2GRM5CHRNA7 | |
| SCHEMBL21723007 | 0.82 | KCNH2 (0.40) | KCNH2GRM5CHRNA7RORCPTGDR2 | |
| SCHEMBL21722921 | 0.79 | RAB9A (0.43) | CHRNA7RORCPTGDR2LMNAFFAR1 | |
| SCHEMBL30707788 | 0.77 | KCNH2 (0.61) | KCNH2GRM5CYP1A2PTGDR2LMNA | |
| SCHEMBL4448140 | 0.77 | KCNH2 (0.61) | KCNH2GRM5CYP1A2PTGDR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927093-B1 | Method for synthesizing 2-benzylidene tetrahydrothiophene derivative | SOOCHOW UNIVERSITY (CN) | 2021-02-23 | — | — | US | claimed |
| US-20210040060-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | SOOCHOW UNIVERSITY (CN) | 2021-02-11 | — | — | US | claimed |
| WO-2019153373-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | 苏州大学张家港工业技术研究院 | 2019-08-15 | — | — | WO | claimed |
| US-20260132147-A1 | BAX INHIBITORS AND USES THEREOF | CASE WESTERN RESERVE UNIV (US) | 2026-05-14 | — | — | US | disclosed |
| US-12479857-B2 | Bax inhibitors and uses thereof | CASE WESTERN RESERVE UNIVERSITY (US) | 2025-11-25 | — | — | US | disclosed |
| US-20220389028-A1 | BAX INHIBITORS AND USES THEREOF | CASE WESTERN RESERVE UNIVERSITY | 2022-12-08 | — | — | US | disclosed |
| US-20220389028-A1 | BAX INHIBITORS AND USES THEREOF | CASE WESTERN RESERVE UNIVERSITY | 2022-12-08 | — | — | US | disclosed |
| US-10927093-B1 | Method for synthesizing 2-benzylidene tetrahydrothiophene derivative | SOOCHOW UNIVERSITY (CN) | 2021-02-23 | — | — | US | disclosed |
| US-10927093-B1 | Method for synthesizing 2-benzylidene tetrahydrothiophene derivative | SOOCHOW UNIVERSITY (CN) | 2021-02-23 | — | — | US | disclosed |
| US-20210040060-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | SOOCHOW UNIVERSITY (CN) | 2021-02-11 | — | — | US | disclosed |
| US-20210040060-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | SOOCHOW UNIVERSITY (CN) | 2021-02-11 | — | — | US | disclosed |
| WO-2021002986-A2 | BAX INHIBITORS AND USES THEREOF | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-01-07 | — | — | WO | disclosed |
| CN-108395423-B | Synthesis method of 2-benzylidene tetrahydrothiophene derivative | 苏州大学 | 2020-05-15 | — | — | CN | disclosed |
| WO-2019153373-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | 苏州大学张家港工业技术研究院 | 2019-08-15 | — | — | WO | disclosed |
| WO-2019153373-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | 苏州大学张家港工业技术研究院 | 2019-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260132147-A1 | BAX INHIBITORS AND USES THEREOF | BAX, BCL2, BAK1 | KCNH2 940/4885GRM5 4277/4885PGK1 3871/4885 |
| US-10927093-B1 | Method for synthesizing 2-benzylidene tetrahydrothiophene derivative | CBR3, TST, C5 | KCNH2 301/4885GRM5 3640/4885PGK1 3742/4885 |
| US-20210040060-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | CBR3, TST, C5 | KCNH2 301/4885GRM5 3640/4885PGK1 3742/4885 |
| US-20220389028-A1 | BAX INHIBITORS AND USES THEREOF | BAX, TMBIM6, BCL2 | KCNH2 4555/4885GRM5 4571/4885PGK1 1082/4885 |
| US-12479857-B2 | Bax inhibitors and uses thereof | BAX, TMBIM6, BCL2 | KCNH2 4555/4885GRM5 4571/4885PGK1 1082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.