SCHEMBL21248077

SCHEMBL21248077

CNC(=O)C(Cl)c1ccc(Cl)cc1C(=O)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.48
LMNA P02545 4/20 0.47
ALDH1A1 P00352 2/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
HTT P42858 3/20 0.46
ATM Q13315 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
MITF O75030 1/20 0.46
HSP90AA1 P07900 1/20 0.46
TLR9 Q9NR96 1/20 0.46
TP53 P04637 3/20 0.45
GABRP O00591 1/20 0.45
GABRD O14764 1/20 0.45
GABRA1 P14867 1/20 0.45
GABRB1 P18505 1/20 0.45
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45
GABRA2 P47869 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31541221 0.84 AKR1C3 (0.46) MAPTLMNAALDH1A1SMN1; SMN2HTT
SCHEMBL11416719 0.80 CHRM1 (0.44) MAPTLMNAALDH1A1SMN1; SMN2
SCHEMBL11738814 0.76 GABRP (0.49) MAPTLMNAALDH1A1SMN1; SMN2HTT
SCHEMBL11657881 0.74 MAPT (0.64) MAPTLMNAALDH1A1SMN1; SMN2TP53
SCHEMBL28157462 0.73 NR4A1 (0.61) MAPTLMNAALDH1A1SMN1; SMN2HTT
SCHEMBL333291 0.73 MAPT (0.67) MAPTLMNAALDH1A1SMN1; SMN2HTT
SCHEMBL31384417 0.73 MAPT (0.67) MAPTLMNAALDH1A1SMN1; SMN2HTT
SCHEMBL9853532 0.73 S100B (0.44) MAPTLMNAALDH1A1SMN1; SMN2HTT
SCHEMBL11681422 0.72 HTT (0.55) MAPTLMNAALDH1A1SMN1; SMN2HTT
SCHEMBL10624160 0.72 HTT (0.55) MAPTLMNAALDH1A1SMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113663463-B Odor inhibitor 日东生物科技(浙江)有限公司 2022-08-02 CN claimed
CN-113663463-A Odor inhibitor 日东生物科技(浙江)有限公司 2021-11-19 CN claimed
US-11961595-B2 Computational generation of chemical synthesis routes and methods SRI INTERNATIONAL (US) 2024-04-16 US disclosed
CN-113663463-B Odor inhibitor 日东生物科技(浙江)有限公司 2022-08-02 CN disclosed
CN-113663463-A Odor inhibitor 日东生物科技(浙江)有限公司 2021-11-19 CN disclosed
US-20210065851-A1 COMPUTATIONAL GENERATION OF CHEMICAL SYNTHESIS ROUTES AND METHODS SRI INTERNATIONAL 2021-03-04 US disclosed
CN-112272764-A Computational generation of chemical synthetic routes and methods 斯坦福国际研究院 2021-01-26 CN disclosed
EP-3746772-A1 COMPUTATIONAL GENERATION OF CHEMICAL SYNTHESIS ROUTES AND METHODS Madrid, Peter (US) 2020-12-09 EP disclosed
WO-2019156872-A9 COMPUTATIONAL GENERATION OF CHEMICAL SYNTHESIS ROUTES AND METHODS MADRID PETER (US) 2019-10-03 WO disclosed
WO-2019156872-A1 COMPUTATIONAL GENERATION OF CHEMICAL SYNTHESIS ROUTES AND METHODS MADRID PETER (US) 2019-08-15 WO disclosed