Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21251985 | 0.90 | PGK1 (0.41) | PGK1CYP1A2CYP3A4CYP2D6HIF1A | |
| SCHEMBL20331085 | 0.81 | PGK1 (0.45) | PGK1PDPK1TLR9FGFR1 | |
| SCHEMBL20330753 | 0.81 | PGK1 (0.46) | PGK1TLR9FGFR1 | |
| SCHEMBL21252510 | 0.80 | FGFR1 (0.49) | PGK1CYP1A2CYP3A4CYP2D6HIF1A | |
| SCHEMBL21240565 | 0.79 | PGK1 (0.44) | PGK1CYP1A2CYP3A4CYP2D6HIF1A | |
| SCHEMBL30046372 | 0.79 | PGK1 (0.44) | PGK1CYP1A2CYP3A4CYP2D6HIF1A | |
| SCHEMBL20332044 | 0.73 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2D6HIF1ALMNA | |
| SCHEMBL20331055 | 0.73 | FGFR1 (0.44) | PGK1CYP1A2CYP3A4CYP2D6HIF1A | |
| SCHEMBL20330743 | 0.73 | SUV39H2 (0.44) | CYP1A2CYP3A4CYP2D6HIF1ALMNA | |
| SCHEMBL20331423 | 0.71 | NOS3 (0.39) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |