Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252283 | 0.92 | MAP3K12 (0.32) | MAP3K12PIK3CAMTORMAP4K1 | |
| SCHEMBL21252007 | 0.90 | PIK3CA (0.36) | PIK3CAMTORMAP4K1 | |
| SCHEMBL20331732 | 0.89 | ABL1 (0.32) | MAP3K12MAP4K1 | |
| SCHEMBL21240064 | 0.88 | PDE9A (0.32) | MAP3K12MAP4K1 | |
| SCHEMBL21252482 | 0.88 | FGFR4 (0.37) | MAP3K12PIK3CAMTOR | |
| SCHEMBL21252008 | 0.86 | GAK (0.37) | MAP3K12PIK3CAMTOR | |
| SCHEMBL21252220 | 0.85 | PIK3CA (0.33) | MAP3K12PIK3CAMTORMAP4K1 | |
| SCHEMBL20332008 | 0.84 | FGFR4 (0.35) | MAP3K12 | |
| SCHEMBL21251781 | 0.84 | JAK2 (0.36) | MAP3K12 | |
| SCHEMBL21252311 | 0.83 | MAP4K1 (0.33) | MAP3K12PIK3CAMTORMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |