Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 7/20 | 0.33 |
| ▸ | WHR1 | P49842 | 2/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | NEK2 | P51955 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252283 | 0.94 | MAP3K12 (0.32) | PIK3CAMTORMAP4K1GAKPRKCA | |
| SCHEMBL21252476 | 0.90 | MAP3K12 (0.34) | PIK3CAMTORMAP4K1 | |
| SCHEMBL21240428 | 0.88 | PDE9A (0.40) | KITWHR1MAP4K1TTKPRKCA | |
| SCHEMBL21251782 | 0.88 | PIK3CA (0.36) | PIK3CAMTORPTPN11 | |
| SCHEMBL21252340 | 0.85 | PIK3CA (0.47) | PIK3CAMTORMAP4K1GAK | |
| SCHEMBL21252039 | 0.84 | TTK (0.37) | PIK3CAMTORKITTTKGAK | |
| SCHEMBL21252194 | 0.83 | PIK3CA (0.36) | PIK3CAMTORWHR1MAP4K1GAK | |
| SCHEMBL20332234 | 0.83 | PDE9A (0.36) | WHR1MAP4K1TTKABL1 | |
| SCHEMBL21252174 | 0.83 | PIK3CA (0.37) | PIK3CAMTORTTKNEK2 | |
| SCHEMBL21251949 | 0.83 | FGFR4 (0.35) | PIK3CAMTORTTKPTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |