Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 6/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19071676 | 0.98 | TDO2 (0.38) | KIF11TOP1TDO2HTR2BHTR5A | |
| SCHEMBL26059229 | 0.96 | TDO2 (0.36) | KIF11TOP1TDO2HTR2BHTR5A | |
| SCHEMBL26057569 | 0.90 | KIF11 (0.36) | KIF11TOP1TDO2HTR2BHTR5A | |
| SCHEMBL19474421 | 0.90 | TDO2 (0.40) | KIF11TOP1TDO2HTR2BHTR5A | |
| SCHEMBL19245324 | 0.90 | TDO2 (0.40) | KIF11TOP1TDO2HTR2BHTR5A | |
| SCHEMBL19933533 | 0.90 | KIF11 (0.35) | KIF11TOP1TDO2HTR2BHTR5A | |
| SCHEMBL26057764 | 0.89 | MEN1 (0.38) | KIF11TOP1TDO2HTR2BHTR5A | |
| SCHEMBL30870481 | 0.89 | GABRP (0.41) | KIF11TOP1TDO2HTR2BHTR5A | |
| SCHEMBL30374874 | 0.89 | GABRP (0.41) | KIF11TOP1TDO2HTR2BHTR5A | |
| SCHEMBL22355457 | 0.89 | GABRP (0.41) | KIF11TOP1TDO2HTR2BHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11145828-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-10-12 | — | — | US | disclosed |
| US-20190252628-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11145828-B2 | Metal complexes | AP1M1, AP2M1, AP3M1 | KIF11 1670/4885TOP1 3519/4885TDO2 3098/4885 |
| US-20190252628-A1 | METAL COMPLEXES | AP1M1, AP2M1, AP3M1 | KIF11 1670/4885TOP1 3519/4885TDO2 3098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.