Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.37 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.37 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.37 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.37 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4F8 | P98187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21266832 | 0.91 | BRD4 (0.40) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL23315002 | 0.75 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9FGFR4 | |
| SCHEMBL21266723 | 0.72 | ALDH1A1 (0.41) | CYP1A2CYP3A4FGFR1FGFR2FGFR3 | |
| SCHEMBL21266722 | 0.71 | CYP1A2 (0.40) | CYP1A2CYP3A4BRD4CRHR1 | |
| SCHEMBL21842167 | 0.68 | BTK (0.51) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL13074291 | 0.67 | ALDH1A1 (0.61) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL13485083 | 0.67 | ALDH1A1 (0.61) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL21266733 | 0.67 | FGFR2 (0.49) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL21266744 | 0.67 | BRD4 (0.34) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL15413109 | 0.65 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C9FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3750880-A1 | PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd (CN) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019154364-A1 | PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR | 南京明德新药研发有限公司 | 2019-08-15 | — | — | WO | disclosed |