Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13835404 | 0.82 | PARP1 (0.54) | HRH3PARP1HTR3EKDM4EHTR3B | |
| SCHEMBL21281585 | 0.81 | PARP1 (0.44) | HRH3ADRB1NPC1RAB9APARP1 | |
| SCHEMBL13835324 | 0.78 | SMPD3 (0.43) | NPC1RAB9APARP1KMT2AHSD17B10 | |
| SCHEMBL21268785 | 0.78 | HTR3A (0.40) | ADRB1ATMKMT2ATSHRHSD17B10 | |
| SCHEMBL13964716 | 0.76 | PARP1 (0.42) | HRH3PARP1HTR3EKDM4EHTR3B | |
| SCHEMBL21273937 | 0.75 | ADRA1A (0.37) | HRH3ADRB1NPC1RAB9APARP1 | |
| SCHEMBL21285495 | 0.75 | PARP1 (0.42) | HRH3ADRB1NPC1RAB9APARP1 | |
| SCHEMBL21268787 | 0.75 | PARP1 (0.42) | HRH3ADRB1NPC1RAB9APARP1 | |
| SCHEMBL22801977 | 0.74 | MAP4K4 (0.49) | NPC1RAB9APARP1ATMLMNA | |
| SCHEMBL21268762 | 0.73 | GPR119 (0.42) | PARP1KMT2AAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527209-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB Biopharma SPRL (BE) | 2019-08-21 | — | — | EP | disclosed |