SCHEMBL21274584

SCHEMBL21274584

Nc1ccc(N2CCN(C(=O)c3ccc(Oc4ccccc4)cc3)CC2)cn1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPC6 Q9Y210 3/20 0.65
SLC6A7 Q99884 2/20 0.63
PARP14 Q460N5 5/20 0.56
PARP10 Q53GL7 5/20 0.56
HTT P42858 3/20 0.55
MAPT P10636 2/20 0.55
CRHBP P24387 1/20 0.55
CRHR2 Q13324 1/20 0.55
CYP3A4 P08684 1/20 0.54
GAA P10253 1/20 0.54
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
MGLL Q99685 2/20 0.51
PARP1 P09874 1/20 0.51
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
PIK3CA P42336 1/20 0.49
MTOR P42345 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29752622 1.00 TRPC6 (0.65) TRPC6SLC6A7PARP14PARP10HTT
SCHEMBL21274589 0.87 TRPC6 (0.56) TRPC6SLC6A7PARP14PARP10HTT
SCHEMBL21274568 0.87 HTT (0.62) TRPC6SLC6A7PARP14PARP10HTT
SCHEMBL29752581 0.87 HTT (0.62) TRPC6SLC6A7PARP14PARP10HTT
SCHEMBL26458620 0.86 SLC6A7 (0.63) TRPC6SLC6A7PARP14PARP10HTT
SCHEMBL16151037 0.82 MAPT (0.70) SLC6A7PARP14PARP10HTTMAPT
SCHEMBL8738577 0.82 PARP14 (0.73) SLC6A7PARP14PARP10HTTMAPT
SCHEMBL21274586 0.80 SLC6A7 (0.61) TRPC6SLC6A7PARP14PARP10HTT
SCHEMBL21274797 0.80 TRPC6 (0.59) TRPC6SLC6A7PARP14PARP10HTT
SCHEMBL21045656 0.79 TRPC6 (1.00) TRPC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4103245-B1 ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES KLINIKUM DER TECHNISCHEN UNIV MUENCHEN TUM KLINIKUM (DE) 2026-04-01 EP disclosed
CN-111868055-B Inhibitors of TRPC6 勃林格殷格翰国际有限公司 2024-03-08 CN disclosed
US-20230137816-A1 ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES DEUTSCHES HERZZENTRUM MUENCHEN DES FREISTAATES BAYERN (DE) 2023-05-04 US disclosed
US-20230137816-A1 ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES DEUTSCHES HERZZENTRUM MUENCHEN DES FREISTAATES BAYERN (DE) 2023-05-04 US disclosed
US-20230137816-A1 ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES DEUTSCHES HERZZENTRUM MUENCHEN DES FREISTAATES BAYERN (DE) 2023-05-04 US disclosed
US-11370771-B2 Inhibitors of TRPC6 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2022-06-28 US disclosed
US-11370771-B2 Inhibitors of TRPC6 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2022-06-28 US disclosed
US-20210053935-A1 INHIBITORS OF TRPC6 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2021-02-25 US disclosed
US-20210053935-A1 INHIBITORS OF TRPC6 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2021-02-25 US disclosed
EP-3752503-A1 INHIBITORS OF TRPC6 Boehringer Ingelheim International GmbH (DE) 2020-12-23 EP disclosed
WO-2019161010-A1 INHIBITORS OF TRPC6 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2019-08-22 WO disclosed
WO-2019161010-A1 INHIBITORS OF TRPC6 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2019-08-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230137816-A1 ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES TRPC6, TRPC1, ORAI1 TRPC6 1/4885SLC6A7 812/4885PARP14 1291/4885
US-20210053935-A1 INHIBITORS OF TRPC6 TRPC6, TRPC1, TRPC4 TRPC6 1/4885SLC6A7 311/4885PARP14 1151/4885
US-11370771-B2 Inhibitors of TRPC6 TRPC6, TRPC1, TRPC4 TRPC6 1/4885SLC6A7 311/4885PARP14 1151/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.