Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 1/20 | 0.73 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.73 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | CRHBP | P24387 | 1/20 | 0.67 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16151037 | 0.94 | MAPT (0.70) | PARP14PARP10SLC6A7MEN1KMT2A | |
| SCHEMBL10721777 | 0.89 | MEN1 (0.87) | SLC6A7MEN1KMT2APOLBMAPT | |
| SCHEMBL8595777 | 0.85 | POLB (0.87) | SLC6A7MEN1KMT2APOLBMAPT | |
| SCHEMBL8161635 | 0.83 | SLC6A7 (1.00) | SLC6A7MEN1KMT2APOLBMAPT | |
| SCHEMBL21274584 | 0.82 | TRPC6 (0.65) | PARP14PARP10SLC6A7MEN1KMT2A | |
| SCHEMBL29752622 | 0.82 | TRPC6 (0.65) | PARP14PARP10SLC6A7MEN1KMT2A | |
| SCHEMBL26458620 | 0.82 | SLC6A7 (0.63) | PARP14PARP10SLC6A7MEN1KMT2A | |
| SCHEMBL21240918 | 0.82 | SLC6A7 (0.63) | PARP14PARP10SLC6A7MEN1KMT2A | |
| SCHEMBL8844981 | 0.82 | ALOX15 (0.72) | PARP14PARP10MEN1KMT2AMAPT | |
| SCHEMBL1711050 | 0.81 | MEN1 (0.74) | SLC6A7MEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130310379-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-11-21 | — | — | US | disclosed |
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310379-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | TET1, TET3, EHMT2 | PARP14 468/4885PARP10 458/4885SLC6A7 4331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.