Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HAT1 | O14929 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 3/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953802 | 0.88 | HCAR3 (0.56) | HCAR3ALDH1A1KDM4EHAT1EP300 | |
| SCHEMBL14416656 | 0.83 | HCAR3 (0.57) | HCAR3ALDH1A1KDM4EHAT1EP300 | |
| SCHEMBL28173145 | 0.82 | HCAR3 (0.58) | HCAR3ALDH1A1KDM4EHAT1EP300 | |
| SCHEMBL1569893 | 0.81 | HCAR3 (0.60) | HCAR3ALDH1A1KDM4EHAT1EP300 | |
| SCHEMBL1569897 | 0.81 | HCAR3 (0.60) | HCAR3ALDH1A1KDM4EHAT1EP300 | |
| SCHEMBL2791509 | 0.81 | HCAR3 (0.59) | HCAR3ALDH1A1KDM4ETLR7FYN | |
| SCHEMBL31588400 | 0.81 | HCAR3 (0.59) | HCAR3ALDH1A1KDM4ETLR7FYN | |
| SCHEMBL13304709 | 0.80 | HCAR3 (0.55) | HCAR3ALDH1A1KDM4EHAT1EP300 | |
| SCHEMBL10026856 | 0.79 | HCAR3 (0.54) | HCAR3ALDH1A1KDM4EHAT1EP300 | |
| SCHEMBL21274631 | 0.78 | HCAR3 (0.52) | HCAR3ALDH1A1KDM4EHAT1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11414384-B2 | P300/CBP hat inhibitors | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2022-08-16 | — | — | US | disclosed |
| EP-3752250-B1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS INC (US) | 2022-08-03 | — | — | EP | disclosed |
| US-20210061762-A1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS, INC. | 2021-03-04 | — | — | US | disclosed |
| US-20210061762-A1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS, INC. | 2021-03-04 | — | — | US | disclosed |
| EP-3752250-A1 | P300/CBP HAT INHIBITORS | Constellation Pharmaceuticals, Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2019161157-A1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMCEUTICALS, INC. (US) | 2019-08-22 | — | — | WO | disclosed |
| WO-2019161157-A1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMCEUTICALS, INC. (US) | 2019-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11414384-B2 | P300/CBP hat inhibitors | EP300, HDAC1, KAT2A | HCAR3 2405/4885ALDH1A1 1211/4885KDM4E 807/4885 |
| US-20210061762-A1 | P300/CBP HAT INHIBITORS | EP300, HDAC1, KAT2A | HCAR3 2405/4885ALDH1A1 1211/4885KDM4E 807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.