SCHEMBL21276148

SCHEMBL21276148

O=C(c1cnn(C(=O)N2CC3CN(Cc4cc(Cl)ccc4Cl)CC3C2)c1)N1CCN(C2CC2)CC1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.58
HRH3 Q9Y5N1 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21276284 0.90 FAAH (0.60) FAAH
SCHEMBL21276218 0.88 FAAH (0.58) FAAH
SCHEMBL21276301 0.84 MGLL (0.51) FAAH
SCHEMBL21276121 0.84 FAAH (0.63) FAAH
SCHEMBL20558172 0.81 FAAH (0.60) FAAH
SCHEMBL21276174 0.81 FAAH (0.56) FAAHHRH3
SCHEMBL21276159 0.78 FAAH (0.45) FAAH
SCHEMBL20557986 0.77 FAAH (0.44) FAAHHRH3
SCHEMBL21276276 0.77 PROKR1 (0.44)
SCHEMBL20567154 0.74 FAAH (1.00) FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10385057-B2 Pyrazole compounds and methods of making and using same LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2019-08-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10385057-B2 Pyrazole compounds and methods of making and using same FAAH, FAAH2, MGLL FAAH 1/4885HRH3 539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.