Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | GRK5 | P34947 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21257965 | 0.92 | FAAH (0.48) | FAAH | |
| SCHEMBL21257993 | 0.91 | FAAH (0.47) | FAAH | |
| SCHEMBL20558170 | 0.91 | FAAH (0.56) | FAAHMGLL | |
| SCHEMBL20558151 | 0.90 | FAAH (0.47) | FAAHS1PR1GRK5CDK8S1PR5 | |
| SCHEMBL21257997 | 0.88 | FAAH (0.49) | FAAHMGLL | |
| SCHEMBL21276123 | 0.88 | FAAH (0.47) | FAAH | |
| SCHEMBL21276222 | 0.88 | CACNA1B (0.46) | FAAHCACNA1B | |
| SCHEMBL21276193 | 0.87 | FAAH (0.50) | FAAH | |
| SCHEMBL20556979 | 0.87 | — | — | |
| SCHEMBL17276675 | 0.86 | FAAH (0.58) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) | 2019-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | FAAH, FAAH2, MGLL | FAAH 1/4885S1PR1 676/4885GRK5 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.