Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21276721 | 0.88 | MCHR1 (0.43) | MCHR1KCNA5ALDH1A1KDM4ELTA4H | |
| SCHEMBL21276739 | 0.81 | RAB9A (0.51) | MCHR1ALDH1A1USP2HPGD | |
| SCHEMBL17447589 | 0.78 | FLT3 (0.61) | MAPK14KITAXLABL1 | |
| SCHEMBL21276719 | 0.73 | HRH3 (0.48) | ALDH1A1SIGMAR1USP2 | |
| SCHEMBL21276703 | 0.73 | FLT3 (0.51) | MCHR1MAPK14ALDH1A1KDM4EKIT | |
| SCHEMBL7353127 | 0.71 | LTA4H (0.58) | KDM4ELTA4HPTGS2 | |
| SCHEMBL21276814 | 0.71 | EPHX2 (0.51) | ALDH1A1KDM4ESIGMAR1USP2 | |
| SCHEMBL17447622 | 0.70 | RET (0.63) | MAPK14KITAXLABL1 | |
| SCHEMBL21276801 | 0.69 | HRH3 (0.55) | SIGMAR1 | |
| SCHEMBL21276708 | 0.69 | HRH3 (0.59) | ALDH1A1SIGMAR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169671-B1 | 1-(5-(TERT.-BUTYL)ISOXAZOL-3-YL)-3-(4-((PHENYL)ETHYNYL)PHENYL)UREA DERIVATIVES AND RELATED COMPOUNDS AS FLT3 INHIBITORS FOR TREATING CANCER | SUNSHINE LAKE PHARMA CO LTD (CN) | 2019-08-21 | — | — | EP | disclosed |