Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 11/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.56 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.56 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.56 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21757528 | 0.90 | HRH3 (0.62) | HRH3KCNH2 | |
| SCHEMBL14368318 | 0.87 | CA12 (0.58) | LTA4HHRH3KDM4EKCNH2 | |
| SCHEMBL21757567 | 0.80 | HRH3 (0.63) | HRH3KCNH2 | |
| SCHEMBL21757596 | 0.80 | TSHR (0.66) | HRH3KDM4EKCNH2 | |
| SCHEMBL2249200 | 0.80 | LTA4H (0.68) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7353075 | 0.80 | PSMB1 (0.66) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL21757629 | 0.79 | HRH3 (0.58) | HRH3KDM4EKCNH2 | |
| SCHEMBL20627046 | 0.79 | NTRK1 (0.63) | HRH3KCNH2 | |
| SCHEMBL23742244 | 0.78 | PSMB1 (0.69) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL225017 | 0.78 | PSMB1 (0.69) | LTA4HHRH3PSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997460-B1 | Benzothiophene compounds as antithrombotic agents and intermediates | LILLY CO ELI (US) | 2002-12-11 | — | — | EP | disclosed |
| US-6133262-A | 3-AMINOBENZO(B)THIOPHENE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| EP-0997460-A1 | Benzothiophene compounds as antithrombotic agents and intermediates | ELI LILLY AND COMPANY (US) | 2000-05-03 | — | — | EP | disclosed |