SCHEMBL2127765

SCHEMBL2127765

C#COC(=O)c1ccccc1C(=O)OC

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.55
LMNA P02545 2/20 0.55
ALDH1A1 P00352 4/20 0.53
HSD17B10 Q99714 3/20 0.53
CFTR P13569 1/20 0.53
KDM4E B2RXH2 5/20 0.52
POLB P06746 1/20 0.52
ATM Q13315 1/20 0.52
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA5A P35218 1/20 0.47
CA9 Q16790 1/20 0.47
MAPT P10636 1/20 0.47
ALOX15 P16050 1/20 0.47
KMT2A Q03164 1/20 0.47
NPC1 O15118 1/20 0.47
SLC6A3 Q01959 3/20 0.46
MYC P01106 1/20 0.46
SLC6A4 P31645 2/20 0.45
GLA P06280 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38734 0.90 NPC1 (0.55) TSHRLMNAALDH1A1HSD17B10CFTR
Dimethyl Phthalate SCHEMBL27930568 0.83 TSHR (0.68) TSHRLMNAALDH1A1HSD17B10CFTR
Dimethyl Phthalate SCHEMBL31024408 0.83 TSHR (0.68) TSHRLMNAALDH1A1HSD17B10CFTR
Dimethyl Phthalate SCHEMBL34630 0.83 TSHR (0.74) TSHRLMNAALDH1A1HSD17B10CFTR
Dimethyl Phthalate SCHEMBL29669976 0.83 TSHR (0.74) TSHRLMNAALDH1A1HSD17B10CFTR
Dimethyl Phthalate SCHEMBL790124 0.83 TSHR (0.74) TSHRLMNAALDH1A1HSD17B10CFTR
Dimethyl Phthalate SCHEMBL29500970 0.83 TSHR (0.74) TSHRLMNAALDH1A1HSD17B10CFTR
SCHEMBL2747010 0.82 ALDH1A1 (0.56) TSHRLMNAALDH1A1HSD17B10KDM4E
Dimethyl Phthalate SCHEMBL30278536 0.81 TSHR (0.71) TSHRLMNAALDH1A1HSD17B10CFTR
Dimethyl Phthalate SCHEMBL28376050 0.81 TSHR (0.71) TSHRLMNAALDH1A1HSD17B10CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2569343-B1 CATALYSIS OF CROSS-LINKING NEXAM CHEMICAL AB (SE) 2015-07-08 EP disclosed
US-20140303328-A1 CROSS-LINKER NEXAM CHEMICAL AB (SE) 2014-10-09 US disclosed
US-8772418-B2 Cross-linker NEXAM CHEMICAL AB (SE) 2014-07-08 US disclosed
EP-2630115-B1 Crosslinking monomers for aliphatic polyamides NEXAM CHEMICAL AB (SE) 2014-05-14 EP disclosed
US-8697823-B2 Catalysis of cross-linking NEXAM CHEMICAL AB (SE) 2014-04-15 US disclosed
US-20130225769-A1 CROSS-LINKER NEXAM CHEMICAL AB (SE) 2013-08-29 US disclosed
EP-2630115-A1 CROSS-LINKER Nexam Chemical AB (SE) 2013-08-28 EP disclosed
US-20130079479-A1 CATALYSIS OF CROSS-LINKING NEXAM CHEMICAL AB (SE) 2013-03-28 US disclosed
EP-2569343-A1 CATALYSIS OF CROSS-LINKING Nexam Chemical AB (SE) 2013-03-20 EP disclosed
WO-2012052550-A1 CROSS-LINKER NEXAM CHEMICAL AB (SE) 2012-04-26 WO disclosed
EP-2444387-A1 Cross-linkable end-cappers for primary amino groups Nexam Chemical AB (SE) 2012-04-25 EP disclosed
WO-2011141578-A1 CATALYSIS OF CROSS-LINKING NEXAM CHEMICAL AB (SE) 2011-11-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140303328-A1 CROSS-LINKER CAPZA2, PAPSS1, CHIA TSHR 3938/4885LMNA 1449/4885ALDH1A1 3095/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.