SCHEMBL21279072

SCHEMBL21279072

Cc1cc(-c2cc(-n3c4cc(-n5c6ccccc6c6ccccc65)ccc4c4ccc(-n5c6ccccc6c6ccccc65)cc43)c(C#N)cc2-n2c3cc(-n4c5ccccc5c5ccccc54)ccc3c3ccc(-n4c5ccccc5c5ccccc54)cc32)nc(C)n1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.34
ALDH1A1 P00352 7/20 0.34
HPGD P15428 6/20 0.34
GAA P10253 6/20 0.34
GLA P06280 4/20 0.33
HSD17B10 Q99714 2/20 0.33
CASP1 P29466 1/20 0.33
RECQL P46063 1/20 0.33
CASP7 P55210 1/20 0.33
S1PR4 O95977 2/20 0.33
S1PR1 P21453 2/20 0.33
LMNA P02545 1/20 0.32
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
MAT2A P31153 2/20 0.31
S1PR2 O95136 1/20 0.31
IMPDH2 P12268 1/20 0.31
L3MBTL1 Q9Y468 2/20 0.30
TSHR P16473 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21279186 0.94 KDM4E (0.34) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL21279113 0.90 KDM4E (0.36) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL21279169 0.89 PDE10A (0.33) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL21279172 0.88 CYP1A2 (0.36) KDM4EALDH1A1HPGDGLAHSD17B10
SCHEMBL21279110 0.87 SLC22A12 (0.31) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL21278881 0.87 TGFBR1 (0.31) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL21279173 0.86 KIF11 (0.41) GAASMN1; SMN2MAT2ATSHR
SCHEMBL23487721 0.86 ALDH1A1 (0.34) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL22563472 0.86 ALDH1A1 (0.34) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL19913222 0.86 ALDH1A1 (0.36) KDM4EALDH1A1HPGDGAAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3399004-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-08-21 EP disclosed