SCHEMBL21279164

SCHEMBL21279164

Cc1ccc2c3ccccc3n(-c3cc(C#N)c(-c4cc(C)nc(C)n4)cc3-n3c4ccccc4c4ccc(C)cc43)c2c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.36
ALDH1A1 P00352 6/20 0.36
GLA P06280 5/20 0.36
GAA P10253 5/20 0.36
HTT P42858 2/20 0.36
GRM2 Q14416 1/20 0.35
HPGD P15428 5/20 0.34
HSD17B10 Q99714 2/20 0.34
CASP1 P29466 1/20 0.34
RECQL P46063 1/20 0.34
CASP7 P55210 1/20 0.34
S1PR4 O95977 2/20 0.33
S1PR1 P21453 2/20 0.33
L3MBTL1 Q9Y468 3/20 0.32
MAPK1 P28482 2/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
CRHBP P24387 1/20 0.32
KMT2A Q03164 1/20 0.32
CRHR2 Q13324 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21279161 0.94 ALDH1A1 (0.33) KDM4EALDH1A1GLAGAAHTT
SCHEMBL21279113 0.94 KDM4E (0.36) KDM4EALDH1A1GLAGAAHTT
SCHEMBL21279186 0.90 KDM4E (0.34) KDM4EALDH1A1GLAGAAHTT
SCHEMBL21279158 0.90 PDE10A (0.33) KDM4EALDH1A1GLAGAAHTT
SCHEMBL21278734 0.88 SLC22A12 (0.31) KDM4EALDH1A1GLAGAAHPGD
SCHEMBL21278803 0.87 AR (0.38) KDM4EALDH1A1GLAGAAHTT
SCHEMBL21278866 0.87 KIF11 (0.41) MEN1KMT2AMAT2ASMN1; SMN2
SCHEMBL21278825 0.86 IRAK4 (0.30)
SCHEMBL19942745 0.85 GRM2 (0.37) KDM4EALDH1A1GLAGAAHTT
SCHEMBL22563563 0.85 GRM2 (0.37) KDM4EALDH1A1GLAGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3399004-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-08-21 EP disclosed