Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 15/20 | 0.51 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214387 | 0.92 | CNR1 (0.61) | CNR1CNR2 | |
| SCHEMBL214846 | 0.89 | CNR1 (0.49) | CNR1CNR2HDAC4HDAC6 | |
| SCHEMBL14856737 | 0.88 | CNR1 (0.46) | CNR1CNR2TRPV1HDAC4HDAC6 | |
| SCHEMBL212455 | 0.87 | CNR1 (0.46) | CNR1CNR2TRPV1HDAC4HDAC6 | |
| SCHEMBL4237852 | 0.85 | CNR1 (0.58) | CNR1CNR2TACR2 | |
| SCHEMBL211995 | 0.82 | CNR1 (0.56) | CNR1CNR2TRPV1HDAC4HDAC6 | |
| SCHEMBL4058840 | 0.81 | KIF11 (0.41) | PPARA | |
| SCHEMBL212187 | 0.80 | CNR1 (0.37) | CNR1CNR2PPARA | |
| SCHEMBL14856867 | 0.80 | CNR1 (0.56) | CNR1CNR2TRPV1 | |
| SCHEMBL213558 | 0.80 | CNR1 (0.55) | CNR1CNR2TRPV1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |