Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21281595 | 0.89 | MAPT (0.38) | AURKACDK4CNR1CNR2MCHR1 | |
| SCHEMBL21273979 | 0.85 | GPR119 (0.39) | CNR1CNR2RORC | |
| SCHEMBL22801947 | 0.85 | GPR119 (0.39) | CNR1CNR2RORC | |
| SCHEMBL21274382 | 0.85 | GPR119 (0.39) | CNR1CNR2RORC | |
| SCHEMBL21285514 | 0.84 | JAK2 (0.35) | AURKACDK4CNR1CNR2MCHR1 | |
| SCHEMBL21274013 | 0.70 | GPR119 (0.41) | — | |
| SCHEMBL22801915 | 0.70 | GPR119 (0.41) | — | |
| SCHEMBL22801952 | 0.70 | GPR119 (0.41) | — | |
| SCHEMBL21281590 | 0.68 | PARP1 (0.36) | AURKACDK4 | |
| SCHEMBL21285460 | 0.65 | AURKA (0.47) | AURKACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527209-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB Biopharma SPRL (BE) | 2019-08-21 | — | — | EP | disclosed |