Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21285460 | 0.83 | AURKA (0.47) | PARP1DHFRAURKACDK4INSR | |
| SCHEMBL21281595 | 0.79 | MAPT (0.38) | AURKACDK4LMNA | |
| SCHEMBL21285548 | 0.72 | PARP1 (0.35) | PARP1AURKACDK4INSRCDK1 | |
| SCHEMBL21285512 | 0.72 | KMT2A (0.43) | PARP1NPC1LMNASMN1; SMN2MEN1 | |
| SCHEMBL21274501 | 0.72 | GPR119 (0.42) | PARP1AURKACDK4INSRCDK1 | |
| SCHEMBL22801948 | 0.72 | GPR119 (0.42) | PARP1AURKACDK4INSRCDK1 | |
| SCHEMBL21274200 | 0.72 | GPR119 (0.42) | PARP1AURKACDK4INSRCDK1 | |
| SCHEMBL22801915 | 0.71 | GPR119 (0.41) | PARP1HSD11B1MEN1KMT2A | |
| SCHEMBL22801952 | 0.71 | GPR119 (0.41) | PARP1HSD11B1MEN1KMT2A | |
| SCHEMBL21281443 | 0.70 | HTR7 (0.44) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527209-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB Biopharma SPRL (BE) | 2019-08-21 | — | — | EP | disclosed |