Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.47 |
| ▸ | CDK4 | P11802 | 5/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 3/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21281590 | 0.83 | PARP1 (0.36) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21285488 | 0.79 | DGAT1 (0.39) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21274289 | 0.76 | GPR119 (0.45) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21281595 | 0.76 | MAPT (0.38) | AURKACDK4MAPT | |
| SCHEMBL21274032 | 0.75 | GPR119 (0.44) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21274324 | 0.75 | GPR119 (0.44) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21274078 | 0.74 | GPR119 (0.43) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21274376 | 0.74 | GPR119 (0.43) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21274074 | 0.74 | GPR119 (0.43) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21281443 | 0.73 | HTR7 (0.44) | PARP1HRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019158731-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-08-22 | — | — | WO | disclosed |