Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 6/20 | 0.60 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19089678 | 0.88 | RPS6KA5 (0.59) | RPS6KA5RPS6KA4FFAR4MAPTALDH1A1 | |
| SCHEMBL27253708 | 0.78 | RPS6KA5 (0.57) | RPS6KA5RPS6KA4MAPTSMN1; SMN2HTT | |
| SCHEMBL5090434 | 0.76 | RPS6KA5 (0.68) | RPS6KA5RPS6KA4MAPTSMN1; SMN2ROCK1 | |
| SCHEMBL19089378 | 0.76 | RPS6KA5 (0.59) | RPS6KA5MAPTHTR2CROCK1 | |
| SCHEMBL8669276 | 0.73 | MAPT (0.53) | MAPTSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL20357808 | 0.73 | RPS6KA5 (0.47) | RPS6KA5RPS6KA4MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL23883999 | 0.70 | FFAR4 (0.52) | FFAR4MAPTSMN1; SMN2ALDH1A1HTR2C | |
| SCHEMBL28337545 | 0.70 | RPS6KA5 (0.53) | RPS6KA5RPS6KA4FFAR4MAPTHTR2C | |
| SCHEMBL30234615 | 0.70 | FFAR4 (0.52) | FFAR4MAPTSMN1; SMN2ALDH1A1HTR2C | |
| SCHEMBL13575104 | 0.68 | TTBK1 (0.39) | RPS6KA5FFAR4ROCK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111247137-A | Pyrimidine compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2020-06-05 | — | — | CN | disclosed |
| WO-2019157959-A1 | PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 恩瑞生物医药科技（上海）有限公司 | 2019-08-22 | — | — | WO | disclosed |