Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | NAE1 | Q13564 | 6/20 | 0.40 |
| ▸ | UBA3 | Q8TBC4 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.35 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21283361 | 0.89 | CRHR1 (0.39) | AURKARPS6KB1NAE1UBA3CA2 | |
| SCHEMBL21283396 | 0.75 | NAE1 (0.42) | AURKARPS6KB1NAE1UBA3CA2 | |
| SCHEMBL21283366 | 0.75 | NAE1 (0.42) | AURKARPS6KB1NAE1UBA3CA2 | |
| SCHEMBL21283412 | 0.75 | NAE1 (0.35) | AURKARPS6KB1NAE1UBA3CA2 | |
| SCHEMBL21283355 | 0.75 | NAE1 (0.35) | AURKARPS6KB1NAE1UBA3CA2 | |
| SCHEMBL21283356 | 0.75 | NAE1 (0.35) | AURKARPS6KB1NAE1UBA3CA2 | |
| SCHEMBL21283375 | 0.75 | NAE1 (0.35) | AURKARPS6KB1NAE1UBA3CA2 | |
| SCHEMBL21283394 | 0.74 | NAE1 (0.39) | AURKARPS6KB1NAE1UBA3CA2 | |
| SCHEMBL21283411 | 0.71 | FFAR1 (0.32) | NAE1UBA3CYP2C9CA2GRK5 | |
| SCHEMBL17866029 | 0.70 | NAE1 (0.49) | AURKARPS6KB1NAE1UBA3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190255052-A1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190255052-A1 | Inhibitors of E1 Activating Enzymes | ECE1, RNASE1, RCE1 | AURKA 1673/4885RPS6KB1 440/4885NAE1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.