Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.30 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.30 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | BCR | P11274 | 1/20 | 0.30 |
| ▸ | GRK5 | P34947 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.30 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21283356 | 0.88 | NAE1 (0.35) | PRMT5SCN9ABMPR1BACVR1BTGFBR1 | |
| SCHEMBL21283375 | 0.88 | NAE1 (0.35) | SCN9ABMPR1BACVR1BTGFBR1ACVRL1 | |
| SCHEMBL21283355 | 0.81 | NAE1 (0.35) | PRMT5WDR77SCN9ANAE1CA2 | |
| SCHEMBL21283412 | 0.81 | NAE1 (0.35) | PRMT5WDR77SCN9ANAE1CA2 | |
| SCHEMBL21283393 | 0.71 | AURKA (0.45) | CYP2C9PRMT5WDR77SCN9ANAE1 | |
| SCHEMBL21283376 | 0.70 | EGFR (0.40) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL21283361 | 0.69 | CRHR1 (0.39) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL17865935 | 0.67 | NAE1 (0.55) | CYP2C8PRMT5WDR77NAE1CA2 | |
| SCHEMBL21283385 | 0.66 | NAE1 (0.52) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL18872389 | 0.65 | NAE1 (0.58) | NAE1CA2GRK5CSNK1A1UBA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190255052-A1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190255052-A1 | Inhibitors of E1 Activating Enzymes | ECE1, RNASE1, RCE1 | FFAR1 3716/4885CYP2C8 1414/4885CYP2C9 2237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.