Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 4/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2128436 | 1.00 | TSHR (0.54) | TSHRALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL16204433 | 0.91 | TSHR (0.66) | TSHRALDH1A1ROCK2CCR2ROCK1 | |
| SCHEMBL8550581 | 0.90 | MAPT (0.57) | TSHRALDH1A1MAPTROCK2CCR2 | |
| SCHEMBL27883982 | 0.82 | MPO (0.62) | TSHRALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL6347933 | 0.81 | KDM4E (0.42) | TSHRALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL6274032 | 0.81 | ACHE (0.45) | TSHRALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL23320598 | 0.81 | TSHR (0.54) | TSHRALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL14344767 | 0.81 | ACHE (0.64) | TSHRALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL21630634 | 0.81 | TSHR (0.54) | TSHRALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL13463043 | 0.81 | MAPT (0.55) | TSHRALDH1A1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361244-B1 | A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES | COUNCIL SCIENT IND RES (IN) | 2013-07-10 | — | — | EP | disclosed |
| US-8445700-B2 | Process for the preparation of optically active N-benzyl-3 hydroxypyrrolidines | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-05-21 | — | — | US | disclosed |
| US-20120101285-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-04-26 | — | — | US | disclosed |
| EP-2361244-A1 | A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES | Council of Scientific & Industrial Research (IN) | 2011-08-31 | — | — | EP | disclosed |
| WO-2010058429-A1 | A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101285-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES | ADA, AMPD3, AMPD2 | TSHR 4395/4885ALDH1A1 687/4885HDAC3 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.