Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743860 | 1.00 | OPRM1 (0.36) | OPRM1OPRD1OPRK1OPRL1DPP4 | |
| SCHEMBL8601625 | 0.95 | OPRM1 (0.39) | OPRM1OPRD1OPRK1OPRL1DPP4 | |
| SCHEMBL9133563 | 0.76 | SLC6A2 (0.33) | OPRM1 | |
| SCHEMBL9133434 | 0.71 | — | — | |
| SCHEMBL6903507 | 0.70 | KMT2A (0.40) | TSHR | |
| SCHEMBL6905915 | 0.70 | KMT2A (0.40) | TSHR | |
| SCHEMBL27896472 | 0.69 | TRPA1 (0.38) | OPRM1OPRL1DPP4 | |
| SCHEMBL21504377 | 0.69 | SCN1A (0.40) | OPRM1OPRL1DPP4TSHR | |
| SCHEMBL7597793 | 0.69 | POLB (0.41) | — | |
| SCHEMBL10942039 | 0.69 | TSHR (0.44) | OPRM1OPRD1OPRK1OPRL1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2442809-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Incorporated (US) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010148197-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-23 | — | — | WO | disclosed |