Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 6/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21285477 | 1.00 | HRH3 (0.39) | HRH3RETCSNK2A1SOS1KDM2B | |
| SCHEMBL21273933 | 0.84 | PARP1 (0.35) | HRH3RETKDM4EJAK2PIM1 | |
| SCHEMBL21274102 | 0.84 | PARP1 (0.35) | HRH3RETKDM4EJAK2PIM1 | |
| SCHEMBL22801965 | 0.84 | PARP1 (0.35) | HRH3RETKDM4EJAK2PIM1 | |
| SCHEMBL22801995 | 0.84 | MAPT (0.34) | RETCDK4CDK6FLT3AXL | |
| SCHEMBL22801994 | 0.84 | MAPT (0.34) | RETCDK4CDK6FLT3AXL | |
| SCHEMBL21274072 | 0.81 | ALDH1A1 (0.37) | RETCDK4CDK6FLT3KDM4E | |
| SCHEMBL21274070 | 0.81 | ALDH1A1 (0.37) | RETCDK4CDK6FLT3KDM4E | |
| SCHEMBL21274333 | 0.81 | GPR119 (0.44) | CYP3A4LRRK2 | |
| SCHEMBL21274490 | 0.81 | HSD11B1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019158731-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-08-22 | — | — | WO | disclosed |