Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | ACACA | Q13085 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22801916 | 0.90 | GPR119 (0.40) | PDE10AGPR119JAK2JAK3 | |
| SCHEMBL22801958 | 0.90 | GPR119 (0.40) | PDE10AGPR119JAK2JAK3 | |
| SCHEMBL22822839 | 0.90 | GPR119 (0.40) | PDE10AGPR119JAK2JAK3 | |
| SCHEMBL22822718 | 0.85 | PDE10A (0.34) | PDE10AGPR119MAPTAURKAPDPK1 | |
| SCHEMBL21281415 | 0.84 | CPB2 (0.34) | PDE10AMAPTAURKAPDPK1AURKB | |
| SCHEMBL21281413 | 0.83 | GPR119 (0.38) | PDE10AGPR119AURKAPDPK1AURKB | |
| SCHEMBL22801961 | 0.83 | RET (0.37) | PDE10AGPR119PIK3R1PIK3CA | |
| SCHEMBL22822830 | 0.83 | GPR119 (0.39) | PDE10AGPR119AURKAPDPK1AURKB | |
| SCHEMBL22801970 | 0.82 | PIK3R1 (0.34) | PDE10AAURKAPDPK1AURKBPIK3R1 | |
| SCHEMBL21268756 | 0.82 | PIK3R1 (0.34) | PDE10AAURKAPDPK1AURKBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019158731-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-08-22 | — | — | WO | disclosed |