Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MCHR2 | Q969V1 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 4/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21274472 | 0.86 | VEGFA (0.37) | SPHK2SPHK1VEGFAEGLN1DRD2 | |
| SCHEMBL21268806 | 0.72 | HRH3 (0.42) | KCNH2 | |
| SCHEMBL21274100 | 0.72 | HRH3 (0.42) | KCNH2 | |
| SCHEMBL21281450 | 0.72 | HRH3 (0.42) | KCNH2 | |
| SCHEMBL21274178 | 0.68 | SLC18A3 (0.35) | HTR2AHTR2CKMT2A | |
| SCHEMBL21274058 | 0.66 | SLC18A3 (0.36) | DRD2KCNH2KMT2AKDM4EALDH1A1 | |
| SCHEMBL21274394 | 0.66 | NPC1 (0.37) | DRD2HTR2AHTR2CHTR1B | |
| SCHEMBL21274036 | 0.66 | NPC1 (0.35) | NTSR1MCHR1KCNH2KMT2A | |
| SCHEMBL22822881 | 0.65 | HTR7 (0.41) | KCNH2HTR6KMT2A | |
| SCHEMBL21281500 | 0.65 | ADRA1A (0.45) | DRD2HTR2AHTR2CHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019158731-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-08-22 | — | — | WO | disclosed |