Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 3/20 | 0.54 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.48 |
| ▸ | WNT3A | P56704 | 5/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21286277 | 0.93 | DEGS1 (0.56) | EP300DEGS1HSD17B10WNT3AMEN1 | |
| SCHEMBL21286268 | 0.83 | ALDH1A1 (0.66) | DEGS1HSD17B10WNT3AMEN1KMT2A | |
| SCHEMBL22953557 | 0.81 | NPC1 (0.68) | EP300DEGS1HSD17B10WNT3AMEN1 | |
| SCHEMBL22953919 | 0.79 | WNT3A (0.69) | WNT3A | |
| SCHEMBL1064387 | 0.77 | ALDH1A1 (0.48) | EP300CACNA1HWNT3ACACNA1GCACNA1I | |
| SCHEMBL22953917 | 0.77 | TSHR (0.61) | EP300DEGS1HSD17B10WNT3ANPC1 | |
| SCHEMBL5833087 | 0.77 | DEGS1 (0.50) | DEGS1HSD17B10WNT3AMEN1KMT2A | |
| SCHEMBL22953913 | 0.76 | EP300 (0.56) | EP300DEGS1HSD17B10WNT3ANPC1 | |
| SCHEMBL24932139 | 0.75 | EP300 (0.45) | EP300DEGS1CACNA1HMAPT | |
| SCHEMBL17654161 | 0.74 | GLS (0.56) | DEGS1HSD17B10WNT3ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019161162-A1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2019-08-22 | — | — | WO | disclosed |