Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20216503 | 1.00 | FLT3 (0.33) | FLT3ALOX5CTSK | |
| SCHEMBL21397758 | 1.00 | FLT3 (0.33) | FLT3ALOX5CTSK | |
| SCHEMBL20259470 | 1.00 | FLT3 (0.33) | FLT3ALOX5CTSK | |
| SCHEMBL21187951 | 1.00 | FLT3 (0.33) | FLT3ALOX5CTSK | |
| SCHEMBL16135305 | 0.99 | FLT3 (0.33) | FLT3ALOX5 | |
| SCHEMBL21397672 | 0.90 | ALOX5 (0.32) | ALOX5 | |
| SCHEMBL20259471 | 0.90 | ALOX5 (0.32) | ALOX5 | |
| SCHEMBL21286634 | 0.90 | ALOX5 (0.32) | ALOX5 | |
| SCHEMBL23219459 | 0.76 | ALDH1A1 (0.32) | — | |
| SCHEMBL21187793 | 0.76 | ALDH1A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10786512-B2 | DNA-PK inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-09-29 | — | — | US | disclosed |
| US-20190255062-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190255062-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | FLT3 1312/4885ALOX5 4695/4885CTSK 369/4885 |
| US-10786512-B2 | DNA-PK inhibitors | POLK, DTYMK, DCK | FLT3 1312/4885ALOX5 4695/4885CTSK 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.