Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29732974 | 0.76 | LMNA (0.46) | LMNAMC4RCHKAALDH1A1HDAC6 | |
| SCHEMBL19778438 | 0.76 | LMNA (0.46) | LMNAMC4RCHKAALDH1A1HDAC6 | |
| SCHEMBL19778437 | 0.76 | LMNA (0.46) | LMNAMC4RCHKAALDH1A1HDAC6 | |
| SCHEMBL6894415 | 0.76 | LMNA (0.68) | LMNAMC4RCHKAALDH1A1HDAC6 | |
| SCHEMBL21388664 | 0.75 | ALDH1A1 (0.50) | LMNAMC4RCHKAALDH1A1HDAC6 | |
| SCHEMBL19778420 | 0.74 | LMNA (0.43) | LMNAMC4RCHKAALDH1A1HDAC6 | |
| SCHEMBL19179414 | 0.74 | HDAC6 (0.48) | CHKAALDH1A1HDAC6NTRK1RAB9A | |
| SCHEMBL14846692 | 0.74 | HDAC6 (0.48) | CHKAALDH1A1HDAC6NTRK1RAB9A | |
| SCHEMBL21378560 | 0.73 | LMNA (0.64) | LMNAMC4RCHKAALDH1A1HDAC6 | |
| SCHEMBL19852589 | 0.73 | LMNA (0.59) | LMNAMC4RCHKAALDH1A1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752626-B2 | Iso-citrate dehydrogenase (IDH) inhibitor | SHANGHAI METON PHARMACEUTICAL CO., LTD (CN) | 2020-08-25 | — | — | US | disclosed |
| US-20190256511-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | ZHEJIANG METON PHARMACEUTICAL CO., LTD (CN) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256511-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | IDH3A, IDH2, IDH1 | LMNA 3740/4885MC4R 4542/4885CHKA 1695/4885 |
| US-10752626-B2 | Iso-citrate dehydrogenase (IDH) inhibitor | IDH3A, IDH2, IDH1 | LMNA 3740/4885MC4R 4542/4885CHKA 1695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.