Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29677209 | 0.82 | THRB (0.57) | MAPTKDM4EALDH1A1GAAGLA | |
| SCHEMBL645169 | 0.79 | MAPT (0.55) | MAPTKDM4EALDH1A1GAAGLA | |
| SCHEMBL7011270 | 0.79 | MAPT (0.62) | MAPTKDM4EALDH1A1GAAGLA | |
| SCHEMBL2218011 | 0.77 | THRB (0.62) | MAPTKDM4EALDH1A1GAAGLA | |
| SCHEMBL29952952 | 0.77 | MAPT (0.68) | MAPTKDM4EALDH1A1GAAGLA | |
| SCHEMBL23022393 | 0.76 | MAPT (0.55) | MAPTKDM4EALDH1A1GAAGLA | |
| SCHEMBL2227865 | 0.76 | ALDH1A1 (0.47) | MAPTKDM4EALDH1A1GAAGLA | |
| SCHEMBL24697550 | 0.74 | KDM4E (0.56) | MAPTKDM4EALDH1A1GAAGLA | |
| SCHEMBL14039272 | 0.72 | KMT2A (0.57) | MAPTKDM4EALDH1A1GAAGLA | |
| SCHEMBL1684145 | 0.72 | PTGS1 (0.53) | MAPTKDM4EALDH1A1GAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019158019-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海青煜医药科技有限公司 | 2019-08-22 | — | — | WO | disclosed |