SCHEMBL2129128

SCHEMBL2129128

ON=C(NC(F)(F)F)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.40
TSHR P16473 4/20 0.40
GAA P10253 3/20 0.40
NPSR1 Q6W5P4 1/20 0.40
CES1 P23141 2/20 0.39
CYP2C19 P33261 1/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
POLB P06746 2/20 0.33
ESR1 P03372 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
P2RX1 P51575 1/20 0.33
HPGD P15428 2/20 0.32
GFER P55789 1/20 0.32
ALOX15 P16050 2/20 0.32
KDM4E B2RXH2 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7625416 0.86 CES1 (0.38) ALDH1A1GAACES1NPC1RAB9A
SCHEMBL3069253 0.79 GAA (0.48) ALDH1A1TSHRGAANPSR1CYP2C19
SCHEMBL27789391 0.75 TSHR (0.37) ALDH1A1TSHRGAANPSR1CES1
SCHEMBL134570 0.73 IDO1 (0.46) ALDH1A1TSHRGAANPSR1CES1
SCHEMBL3942966 0.73 IDO1 (0.46) ALDH1A1TSHRGAANPSR1CES1
SCHEMBL10703398 0.72 TSHR (0.57) ALDH1A1TSHRGAANPSR1CES1
SCHEMBL6996061 0.72 TSHR (0.57) ALDH1A1TSHRGAANPSR1CES1
SCHEMBL3960842 0.71 GAA (0.43) ALDH1A1TSHRGAANPSR1CES1
SCHEMBL18706885 0.71 ALDH1A1 (0.43) ALDH1A1TSHRGAANPSR1CES1
SCHEMBL3773521 0.71 GAA (0.44) ALDH1A1TSHRGAANPSR1CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106916116-B A kind of high yield contains α, the environment-friendly preparation method of the 1 of beta unsaturated ketone, 2,4- furodiazole compounds 山东大学 2019-06-28 CN claimed
CN-106916116-A It is a kind of to contain α, the environment-friendly preparation method of the 1 of beta unsaturated ketone, 2,4 oxadiazole class compounds in high yield 山东大学 2017-07-04 CN claimed
CN-103087054-B 4-pyridine phenyl ether compounds and preparation method thereof and application SHANDONG UNIVERSITY (CN) 2015-12-23 CN claimed
EP-1587784-B1 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2014-10-15 EP claimed
US-8486203-B2 Conversion coating and anodizing sealer with no chromium METALAST INTERNATIONAL, INC. (US) 2013-07-16 US claimed
CN-103087054-A 4-pyridyl phenyl ether compounds, and preparation method and application thereof UNIV SHANDONG 2013-05-08 CN claimed
US-20100314004-A1 CONVERSION COATING AND ANODIZING SEALER WITH NO CHROMIUM CHEMEON SURFACE TECHNOLOGY, LLC 2010-12-16 US claimed
EP-1730232-B1 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2010-10-20 EP claimed
US-7521510-B2 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC (US) 2009-04-21 US claimed
US-7514506-B2 Fast curing fluoroelastomeric compositions, adhesive fluoroelastomeric compositions and methods for bonding fluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2009-04-07 US claimed
EP-1587784-A4 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2008-10-29 EP claimed
EP-1730232-A4 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2008-05-21 EP claimed
US-20070027260-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2007-02-01 US claimed
US-20060287438-A1 Fast curing fluoroelastomeric compositions, adhesive fluoroelastomeric compositions and methods for bonding fluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. 2006-12-21 US claimed
EP-1730232-A2 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2006-12-13 EP claimed
EP-1587784-A2 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2005-10-26 EP claimed
WO-2005097890-A2 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2005-10-20 WO claimed
US-20040214956-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. 2004-10-28 US claimed
WO-2004069900-A2 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2004-08-19 WO claimed
EP-3461849-B1 METHOD OF BONDING PERFLUOROELASTOMERIC MATERIALS TO A SURFACE GREENE TWEED TECH INC (US) 2025-12-10 EP disclosed
US-11390726-B2 Method of bonding perfluoroelastomeric materials to a surface GREENE, TWEED TECHNOLOGIES, INC. (US) 2022-07-19 US disclosed
US-20210198447-A1 Method of Bonding Perfluoroelastomeric Materials to a Surface GREENE, TWEED OF DELAWARE, INC. 2021-07-01 US disclosed
EP-2617738-B1 METHOD OF BONDING PERFLUOROELASTOMERIC MATERIALS TO A SURFACE GREENE TWEED TECH INC (US) 2021-05-05 EP disclosed
US-10961369-B2 Method of bonding perfluoroelastomeric materials to a surface Green, Tweed Technologies (US) 2021-03-30 US disclosed
CN-106916116-B A kind of high yield contains α, the environment-friendly preparation method of the 1 of beta unsaturated ketone, 2,4- furodiazole compounds 山东大学 2019-06-28 CN disclosed
EP-3461849-A1 METHOD OF BONDING PERFLUOROELASTOMERIC MATERIALS TO A SURFACE Greene, Tweed Technologies, Inc. (US) 2019-04-03 EP disclosed
CN-106916116-A It is a kind of to contain α, the environment-friendly preparation method of the 1 of beta unsaturated ketone, 2,4 oxadiazole class compounds in high yield 山东大学 2017-07-04 CN disclosed
CN-103087054-B 4-pyridine phenyl ether compounds and preparation method thereof and application SHANDONG UNIVERSITY (CN) 2015-12-23 CN disclosed
US-20140305588-A1 Method of Bonding Perfluoroelastomeric Materials to a Surface GREENE, TWEED OF DELAWARE, INC. (US) 2014-10-16 US disclosed
EP-1587784-B1 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2014-10-15 EP disclosed
US-20140044974-A1 Inert Substrate-Bonded Fluoroelastomer Components and Related Methods GREENE, TWEED OF DELAWARE, INC. (US) 2014-02-13 US disclosed
EP-2629970-A2 FLUOROELASTOMER BONDING COMPOSITIONS SUITABLE FOR HIGH-TEMPERATURE APPLICATIONS Greene, Tweed Of Delaware, Inc. (US) 2013-08-28 EP disclosed
EP-2617738-A1 Method of bonding perfluoroelastomeric materials to a surface GREENE, TWEED OF DELAWARE, INC. (US) 2013-07-24 EP disclosed
US-8486203-B2 Conversion coating and anodizing sealer with no chromium METALAST INTERNATIONAL, INC. (US) 2013-07-16 US disclosed
CN-103087054-A 4-pyridyl phenyl ether compounds, and preparation method and application thereof UNIV SHANDONG 2013-05-08 CN disclosed
EP-2552979-A1 FLUOROELASTOMER COMPOSITIONS HAVING SELF-BONDING CHARACTERISTICS AND METHODS OF MAKING SAME Greene, Tweed Of Delaware, Inc. (US) 2013-02-06 EP disclosed
CN-102459203-A Compositions and methods for modulating retinol binding to retinol binding protein 4(RBP4) IRM LLC 2012-05-16 CN disclosed
US-20120100379-A1 FLUOROELASTOMER BONDING COMPOSITIONS SUITABLE FOR HIGH-TEMPERATURE APPLICATIONS GREENE, TWEED OF DELAWARE, INC. (US) 2012-04-26 US disclosed
WO-2012054685-A2 FLUOROELASTOMER BONDING COMPOSITIONS SUITABLE FOR HIGH-TEMPERATURE APPLICATIONS GREENE, TWEED OF DELAWARE, INC. (US) 2012-04-26 WO disclosed
WO-2011123339-A1 FLUOROELASTOMER COMPOSITIONS HAVING SELF-BONDING CHARACTERISTICS AND METHODS OF MAKING SAME GREENE, TWEED OF DELAWARE, INC (US) 2011-10-06 WO disclosed
US-20110236692-A1 FLUOROELASTOMER COMPOSITIONS HAVING SELF-BONDING CHARACTERISTICS AND METHODS OF MAKING SAME GREENE, TWEED OF DELAWARE, INC. (US) 2011-09-29 US disclosed
US-20100314004-A1 CONVERSION COATING AND ANODIZING SEALER WITH NO CHROMIUM CHEMEON SURFACE TECHNOLOGY, LLC 2010-12-16 US disclosed
EP-1730232-B1 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2010-10-20 EP disclosed
US-20090301712-A1 Inert Substrate-Bonded Fluoroelastomer Components and Related Methods GREENE, TWEED OF DELAWARE, INC. (US) 2009-12-10 US disclosed
EP-2115012-A1 METHOD OF BONDING PERFLUOROELASTOMERIC MATERIALS TO A SURFACE GREENE, TWEED OF DELAWARE, INC. (US) 2009-11-11 EP disclosed
WO-2009121012-A1 INERT SUBSTRATE-BONDED FLUOROELASTOMETER COMPONENTS AND RELATED METHODS GREENE, TWEED OF DELAWARE, INC. (US) 2009-10-01 WO disclosed
EP-2105465-A1 Inert Substrate-Bonded Perfluoroelastomer Components and Related Methods Greene, Tweed Of Delaware, Inc. (US) 2009-09-30 EP disclosed
US-7521510-B2 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC (US) 2009-04-21 US disclosed
US-7514506-B2 Fast curing fluoroelastomeric compositions, adhesive fluoroelastomeric compositions and methods for bonding fluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2009-04-07 US disclosed
US-20090018275-A1 Method of Bonding Perfluoroelastomeric Materials to a Surface GREENE, TWEED OF DELAWARE, INC. (US) 2009-01-15 US disclosed
EP-1587784-A4 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2008-10-29 EP disclosed
WO-2008094758-A1 METHOD OF BONDING PERFLUOROELASTOMERIC MATERIALS TO A SURFACE GREENE, TWEED OF DELAWARE, INC. (US) 2008-08-07 WO disclosed
EP-1730232-A4 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2008-05-21 EP disclosed
US-7247749-B2 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2007-07-24 US disclosed
US-20070027260-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2007-02-01 US disclosed
US-20060287438-A1 Fast curing fluoroelastomeric compositions, adhesive fluoroelastomeric compositions and methods for bonding fluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. 2006-12-21 US disclosed
EP-1730232-A2 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2006-12-13 EP disclosed
EP-1587784-A2 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2005-10-26 EP disclosed
WO-2005097890-A2 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2005-10-20 WO disclosed
CN-1638776-A Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs CYTOVIA INC (US) 2005-07-13 CN disclosed
US-20050020859-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2005-01-27 US disclosed
WO-2005000917-A1 BISAMINOPEHNYL-BASED CURATIVES CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS. GREENE, TWEED OF DELAWARE, INC. (US) 2005-01-06 WO disclosed
US-20040214956-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. 2004-10-28 US disclosed
WO-2004069900-A2 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2004-08-19 WO disclosed
EP-1406632-A2 SUBSTITUTED 3-ARYL-5-ARYL- 1,2,4]-OXADIAZOLES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF Cytovia, Inc. (US) 2004-04-14 EP disclosed
WO-2002100826-A2 SUBSTITUTED 3-ARYL-5-ARYL-[1,2,4]-OXADIAZOLES AND ANALOGS CYTOVIA, INC. (US) 2002-12-19 WO disclosed
WO-2002100826-A2 SUBSTITUTED 3-ARYL-5-ARYL-[1,2,4]-OXADIAZOLES AND ANALOGS CYTOVIA, INC. (US) 2002-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050020859-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions PFAS, FPGS, ALKBH2 ALDH1A1 1475/4885TSHR 1694/4885GAA 1546/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.