Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.34 |
| ▸ | APP | P05067 | 6/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL511864 | 0.78 | CYP3A4 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL512633 | 0.71 | CYP3A4 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL513773 | 0.70 | CYP3A4 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL512496 | 0.69 | SLC6A2 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19787530 | 0.69 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10279539 | 0.68 | CYP3A4 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL511793 | 0.67 | UGT1A1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL512635 | 0.67 | ADORA3 (0.33) | ADORA3 | |
| SCHEMBL21001315 | 0.67 | UGT1A1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18559791 | 0.66 | CYP3A4 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10669276-B2 | Fused pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190256517-A1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256517-A1 | FUSED PYRIMIDINE DERIVATIVES | C9, APP, HPGDS | PSEN1 16/4885PSEN2 32/4885APH1B 31/4885 |
| US-10669276-B2 | Fused pyrimidine derivatives | APP, APOB, C9 | PSEN1 11/4885PSEN2 18/4885APH1B 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.