Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23768982 | 0.88 | HPGD (0.63) | HPGDPOLBALDH1A1MAPTVCAM1 | |
| SCHEMBL8102330 | 0.85 | HPGD (0.60) | HPGDPOLBALDH1A1MAPTVCAM1 | |
| SCHEMBL14476018 | 0.85 | HPGD (0.67) | HPGDPOLBALDH1A1MAPTVCAM1 | |
| SCHEMBL5917877 | 0.84 | HPGD (0.66) | HPGDPOLBALDH1A1MAPTVCAM1 | |
| SCHEMBL1995617 | 0.84 | HPGD (0.59) | HPGDPOLBALDH1A1MAPTVCAM1 | |
| SCHEMBL5300903 | 0.83 | HPGD (0.58) | HPGDPOLBALDH1A1MAPTVCAM1 | |
| SCHEMBL7357430 | 0.83 | HPGD (0.64) | HPGDPOLBALDH1A1MAPTVCAM1 | |
| SCHEMBL11973051 | 0.82 | POLB (0.72) | HPGDPOLBALDH1A1MAPTVCAM1 | |
| SCHEMBL8892679 | 0.81 | HPGD (0.62) | HPGDPOLBALDH1A1MAPTAPEX1 | |
| SCHEMBL8418979 | 0.81 | HPGD (0.56) | HPGDPOLBALDH1A1MAPTVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220023311-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES INC (US) | 2022-01-27 | — | — | US | disclosed |
| US-10987360-B2 | Hepatitis B core protein modulators | ASSEMBLY BIOSCIENCES, INC. (US) | 2021-04-27 | — | — | US | disclosed |
| US-20190255067-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES INC (US) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10987360-B2 | Hepatitis B core protein modulators | HAVCR2, FABP1, MAVS | HPGD 2902/4885POLB 1770/4885ALDH1A1 3992/4885 |
| US-20190255067-A1 | HEPATITIS B CORE PROTEIN MODULATORS | HAVCR2, FABP1, MAVS | HPGD 2902/4885POLB 1770/4885ALDH1A1 3992/4885 |
| US-20220023311-A1 | HEPATITIS B CORE PROTEIN MODULATORS | HAVCR2, FABP1, MAVS | HPGD 2902/4885POLB 1770/4885ALDH1A1 3992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.