Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.54 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.54 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | RARB | P10826 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.54 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523336 | 1.00 | PTGS2 (0.59) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL13291917 | 0.94 | PTGS2 (0.61) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL12884181 | 0.94 | PTGS2 (0.64) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL9231105 | 0.90 | PTGS2 (0.50) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL13291872 | 0.89 | PTGS2 (0.59) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL3105481 | 0.89 | PTGS2 (0.59) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL3105475 | 0.89 | PTGS2 (0.59) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL13291871 | 0.89 | PTGS2 (0.59) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL8024626 | 0.88 | PTGS2 (0.64) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL11572717 | 0.88 | PTGS2 (0.64) | PTGS2PTGS1CXCR1CXCR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638505-B1 | AMPHIPHILIC PYRIDINIUM COMPOUNDS, METHOD OF MAKING AND USE THEREOF | JACKSON H M FOUND MILITARY MED (US) | 2012-04-25 | — | — | EP | claimed |
| EP-1638505-A4 | AMPHIPHILIC PYRIDINIUM COMPOUNDS, METHOD OF MAKING AND USE THEREOF | JACKSON H M FOUND MILITARY MED (US) | 2009-01-07 | — | — | EP | claimed |
| US-20070105916-A1 | Amphiphilic pyridinium compounds, method of making and use thereof | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. | 2007-05-10 | — | — | US | claimed |
| EP-1638505-A2 | AMPHIPHILIC PYRIDINIUM COMPOUNDS, METHOD OF MAKING AND USE THEREOF | HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2005002519-A2 | AMPHIPHILIC PYRIDINIUM COMPOUNDS, METHOD OF MAKING AND USE THEREOF | HENRY M.JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2005-01-13 | — | — | WO | claimed |
| EP-1638505-A4 | AMPHIPHILIC PYRIDINIUM COMPOUNDS, METHOD OF MAKING AND USE THEREOF | JACKSON H M FOUND MILITARY MED (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1638505-A2 | AMPHIPHILIC PYRIDINIUM COMPOUNDS, METHOD OF MAKING AND USE THEREOF | HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005002519-A2 | AMPHIPHILIC PYRIDINIUM COMPOUNDS, METHOD OF MAKING AND USE THEREOF | HENRY M.JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105916-A1 | Amphiphilic pyridinium compounds, method of making and use thereof | CXCL8, IL18, CCR8 | PTGS2 544/4885PTGS1 421/4885CXCR1 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.