Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 2/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.82 |
| ▸ | MAPT | P10636 | 10/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 8/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.72 |
| ▸ | HTT | P42858 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.65 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.65 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | CCR6 | P51684 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21292771 | 1.00 | PHGDH (0.82) | PHGDHKDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL21292819 | 0.95 | PHGDH (0.79) | PHGDHKDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL16035055 | 0.95 | PHGDH (0.79) | PHGDHKDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL21292675 | 0.94 | PHGDH (0.81) | PHGDHKDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL21292677 | 0.94 | PHGDH (0.81) | PHGDHKDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL21292662 | 0.93 | PHGDH (0.76) | PHGDHKDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL21292753 | 0.93 | PHGDH (0.76) | PHGDHKDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL21292664 | 0.93 | PHGDH (0.76) | PHGDHKDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL21292827 | 0.93 | PHGDH (0.76) | PHGDHKDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL21292807 | 0.93 | PHGDH (0.76) | PHGDHKDM4EMAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10722489-B2 | D-3-phosphoglycerate dehydrogenase allosteric inhibitor and use thereof | PEKING UNIVERSITY (CN) | 2020-07-28 | — | — | US | disclosed |
| US-20200054593-A1 | D-3-PHOSPHOGLYCERATE DEHYDROGENASE ALLOSTERIC INHIBITOR AND USE THEREOF | UNIV BEIJING (CN) | 2020-02-20 | — | — | US | disclosed |
| US-20190262303-A1 | D-3-PHOSPHOGLYCERATE DEHYDROGENASE ALLOSTERIC INHIBITOR AND USE THEREOF | UNIV BEIJING (CN) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10722489-B2 | D-3-phosphoglycerate dehydrogenase allosteric inhibitor and use thereof | MDH2, MDH1, DLD | PHGDH 4/4885KDM4E 1863/4885MAPT 3785/4885 |
| US-20200054593-A1 | D-3-PHOSPHOGLYCERATE DEHYDROGENASE ALLOSTERIC INHIBITOR AND USE THEREOF | MDH2, MDH1, DLD | PHGDH 4/4885KDM4E 1863/4885MAPT 3785/4885 |
| US-20190262303-A1 | D-3-PHOSPHOGLYCERATE DEHYDROGENASE ALLOSTERIC INHIBITOR AND USE THEREOF | MDH2, MDH1, DLD | PHGDH 4/4885KDM4E 1863/4885MAPT 3785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.