SCHEMBL212929

SCHEMBL212929

C(=N/O[Si](c1ccccc1)(c1ccccc1)c1ccccc1)\c1cnccn1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CTH P32929 1/20 0.35
KMT2A Q03164 3/20 0.34
RAB9A P51151 2/20 0.34
MAOA P21397 1/20 0.33
CYP19A1 P11511 1/20 0.33
CYP11B2 P19099 1/20 0.33
TAAR1 Q96RJ0 1/20 0.32
MEN1 O00255 2/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
USP2 O75604 1/20 0.31
NR4A1 P22736 1/20 0.31
MAPT P10636 2/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
KDM4E B2RXH2 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL212930 1.00 CTH (0.35) CTHKMT2ARAB9AMAOACYP19A1
SCHEMBL212865 0.82 MAOA (0.51) KMT2ARAB9AMAOAMEN1NPC1
SCHEMBL212864 0.82 MAOA (0.51) KMT2ARAB9AMAOAMEN1NPC1
SCHEMBL212422 0.78 CTH (0.43) CTHKMT2ARAB9A
SCHEMBL212423 0.78 CTH (0.43) CTHKMT2ARAB9A
SCHEMBL214074 0.78 TAAR1 (0.38) CTHKMT2ARAB9AMAOACYP19A1
SCHEMBL214073 0.78 TAAR1 (0.38) CTHKMT2ARAB9AMAOACYP19A1
SCHEMBL17257463 0.73 NPC1 (0.33) RAB9ACYP19A1CYP11B2NPC1MAPT
SCHEMBL17257462 0.73 NPC1 (0.33) RAB9ACYP19A1CYP11B2NPC1MAPT
SCHEMBL214983 0.72 LMNA (0.44) CTHKMT2ARAB9ATAAR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088868-B2 oximation of cojugated homopolymers formed by addtion polymerization of conjugated diene monomer in the presence lanthanide copmpounds as polymerization catalysts; polymers used in the manufacture of tires having reduced hysteresis BRIDGESTONE CORPORATION (JP) 2012-01-03 US claimed
US-20080146745-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS BRIDGESTONE CORPORATION (JP) 2008-06-19 US claimed
US-8088868-B2 oximation of cojugated homopolymers formed by addtion polymerization of conjugated diene monomer in the presence lanthanide copmpounds as polymerization catalysts; polymers used in the manufacture of tires having reduced hysteresis BRIDGESTONE CORPORATION (JP) 2012-01-03 US disclosed
US-20080146745-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS BRIDGESTONE CORPORATION (JP) 2008-06-19 US disclosed