Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2130196 | 0.79 | MAPT (0.39) | CYP3A4LMNAMAPTALDH1A1GAA | |
| SCHEMBL2128405 | 0.70 | ALDH1A1 (0.52) | HTR1AHTR2CTSHRLMNAMAPT | |
| SCHEMBL24926176 | 0.70 | SMN1; SMN2 (0.50) | CYP3A4TSHRLMNAMAPTNPSR1 | |
| SCHEMBL28421554 | 0.69 | CSNK2A1 (0.33) | CYP1A2MAPTALDH1A1 | |
| SCHEMBL31571429 | 0.68 | CYP1A1 (0.40) | MAPTALDH1A1CYP19A1 | |
| SCHEMBL3751809 | 0.68 | CYP1A1 (0.40) | MAPTALDH1A1CYP19A1 | |
| SCHEMBL19612192 | 0.67 | SMN1; SMN2 (0.47) | CYP3A4LMNAMAPTNPSR1ALDH1A1 | |
| SCHEMBL31507661 | 0.67 | SRC (0.44) | CYP3A4TSHRMAPTNPSR1ALDH1A1 | |
| SCHEMBL4114610 | 0.67 | GAA (0.42) | HTR1AHTR2AHTR2CHTR2BCYP3A4 | |
| SCHEMBL3293006 | 0.66 | ALDH1A1 (0.50) | CYP3A4TSHRLMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170020840-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LTD (AU) | 2017-01-26 | — | — | US | disclosed |
| US-9346842-B2 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2016-05-24 | — | — | US | disclosed |
| US-20140171642-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2014-06-19 | — | — | US | disclosed |
| US-8716335-B2 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2014-05-06 | — | — | US | disclosed |
| US-8680135-B2 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2014-03-25 | — | — | US | disclosed |
| US-20130053351-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2013-02-28 | — | — | US | disclosed |
| US-20120214770-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2012-08-23 | — | — | US | disclosed |
| US-8198466-B2 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2012-06-12 | — | — | US | disclosed |
| EP-2460793-A1 | Substituted Benzofurans, Benzothiophenes, Benzoselenophenes and Indoles And Their Use as Tubulin Polymerisation Inhibitors | Bionomics Limited (AU) | 2012-06-06 | — | — | EP | disclosed |
| EP-1984333-B1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LTD (AU) | 2012-04-25 | — | — | EP | disclosed |
| US-20100004208-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2010-01-07 | — | — | US | disclosed |
| EP-1984333-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | Bionomics Limited (AU) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087684-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214770-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | HTR1A 2270/4885HTR2A 2632/4885HTR2C 1902/4885 |
| US-20170020840-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | HTR1A 2270/4885HTR2A 2632/4885HTR2C 1902/4885 |
| US-20100004208-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | HTR1A 2270/4885HTR2A 2632/4885HTR2C 1902/4885 |
| US-20140171642-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | HTR1A 2270/4885HTR2A 2632/4885HTR2C 1902/4885 |
| US-20130053351-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | HTR1A 2270/4885HTR2A 2632/4885HTR2C 1902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.