Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21294488 | 0.83 | CA12 (0.43) | MAPTALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL31250642 | 0.83 | CA12 (0.43) | MAPTALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL31251103 | 0.79 | PIN1 (0.38) | MAPTALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL21294560 | 0.79 | BCHE (0.36) | ALDH1A1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL18839589 | 0.77 | PLAU (0.41) | MAPTALDH1A1LMNAPIN1POLB | |
| SCHEMBL18839864 | 0.77 | MYC (0.39) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL18839861 | 0.77 | MYC (0.39) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL16321377 | 0.76 | HTT (0.37) | MAPTNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL325598 | 0.76 | ESR1 (0.42) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31251039 | 0.76 | PIN1 (0.38) | MAPTALDH1A1NPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10689366-B2 | Compounds for MALT1 degredation | CORNELL UNIVERSITY (US) | 2020-06-23 | — | — | US | disclosed |
| EP-3535254-A1 | COMPOUNDS FOR MALT1 DEGRADATION | Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") (US) | 2019-09-11 | — | — | EP | disclosed |
| US-20190263785-A1 | COMPOUNDS FOR MALT1 DEGRADATION | CORNELL UNIVERSITY (US) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689366-B2 | Compounds for MALT1 degredation | CRBN, NFKB2, NFKB1 | MAPT 3211/4885ALDH1A1 2961/4885NPC1 1096/4885 |
| US-20190263785-A1 | COMPOUNDS FOR MALT1 DEGRADATION | CRBN, NFKB2, NFKB1 | MAPT 2848/4885ALDH1A1 3324/4885NPC1 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.