Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 4/20 | 0.32 |
| ▸ | CTSS | P25774 | 3/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21294449 | 1.00 | AAK1 (0.35) | AAK1MMP13CA1CA2CA7 | |
| SCHEMBL18787668 | 0.86 | CYP2D6 (0.36) | AAK1MMP13CA1CA2CA7 | |
| SCHEMBL18787667 | 0.86 | CYP2D6 (0.36) | AAK1MMP13CA1CA2CA7 | |
| SCHEMBL31485762 | 0.85 | CA2 (0.36) | AAK1MMP13CA1CA2CA7 | |
| SCHEMBL19812728 | 0.83 | CA1 (0.35) | AAK1MMP13CA1CA2CA7 | |
| SCHEMBL22485387 | 0.82 | AAK1 (0.34) | AAK1MMP13CA1CA2CA7 | |
| SCHEMBL14924779 | 0.81 | GAA (0.41) | AAK1CA1CA2GAACTSK | |
| SCHEMBL5642236 | 0.80 | MMP13 (0.39) | AAK1MMP13CA1CA2CA7 | |
| SCHEMBL25499813 | 0.80 | AAK1 (0.34) | AAK1MMP13GAAHDAC6CYP2D6 | |
| SCHEMBL342693 | 0.80 | AAK1 (0.33) | AAK1MMP13CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10689366-B2 | Compounds for MALT1 degredation | CORNELL UNIVERSITY (US) | 2020-06-23 | — | — | US | disclosed |
| EP-3535254-A1 | COMPOUNDS FOR MALT1 DEGRADATION | Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") (US) | 2019-09-11 | — | — | EP | disclosed |
| US-20190263785-A1 | COMPOUNDS FOR MALT1 DEGRADATION | CORNELL UNIVERSITY (US) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689366-B2 | Compounds for MALT1 degredation | CRBN, NFKB2, NFKB1 | AAK1 996/4885MMP13 3903/4885CA1 2550/4885 |
| US-20190263785-A1 | COMPOUNDS FOR MALT1 DEGRADATION | CRBN, NFKB2, NFKB1 | AAK1 884/4885MMP13 3932/4885CA1 2693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.