Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.47 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 3/20 | 0.43 |
| ▸ | TDP2 | O95551 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.43 |
| ▸ | HK1 | P19367 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CDC25A | P30304 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MITF | O75030 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butanol SCHEMBL1458212 | 0.83 | IDO1 (0.54) | IDO1DNMT1DNMT3LDNMT3AS100A4 | |
| SCHEMBL29440919 | 0.82 | IDO1 (0.68) | IDO1DNMT1DNMT3LDNMT3AS100A4 | |
| SCHEMBL119489 | 0.82 | IDO1 (0.68) | IDO1DNMT1DNMT3LDNMT3AS100A4 | |
| Methylene Chloride SCHEMBL6033829 | 0.81 | IDO1 (0.60) | IDO1DNMT1DNMT3LDNMT3AS100A4 | |
| Trifluoroacetic Acid SCHEMBL4267259 | 0.81 | IDO1 (0.47) | IDO1DNMT1DNMT3LDNMT3AS100A4 | |
| Formic Acid SCHEMBL29070823 | 0.78 | IDO1 (0.56) | IDO1DNMT1DNMT3LDNMT3AS100A4 | |
| SCHEMBL27864640 | 0.69 | IDO1 (0.58) | IDO1DNMT1DNMT3LDNMT3AS100A4 | |
| Dichlon SCHEMBL45723 | 0.67 | IDO1 (1.00) | IDO1DNMT1DNMT3LDNMT3AS100A4 | |
| SCHEMBL29563346 | 0.67 | RAB9A (0.68) | IDO1DNMT1DNMT3LDNMT3AS100A4 | |
| SCHEMBL1510327 | 0.67 | RAB9A (0.68) | IDO1DNMT1DNMT3LDNMT3AS100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11884661-B2 | 3-substituted propionic acids as αV integrin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-30 | — | — | US | disclosed |
| US-10968219-B2 | 3-substituted propionic acids as αV integrin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-04-06 | — | — | US | disclosed |
| US-20190263808-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263808-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | ITGAV, ITGB3, ITGB1 | IDO1 1730/4885DNMT1 4417/4885DNMT3L 4410/4885 |
| US-11884661-B2 | 3-substituted propionic acids as αV integrin inhibitors | ITGB3, ITGB1, ITGAV | IDO1 2908/4885DNMT1 4772/4885DNMT3L 4598/4885 |
| US-10968219-B2 | 3-substituted propionic acids as αV integrin inhibitors | ITGB3, ITGB1, ITGAV | IDO1 1987/4885DNMT1 4466/4885DNMT3L 4347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.