SCHEMBL21295530

SCHEMBL21295530

CN(C)C(=O)COc1cc(NC(=O)Nc2ccccc2)ccc1Oc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.53
MCHR1 Q99705 5/20 0.49
GPR174 Q9BXC1 1/20 0.46
KDR P35968 2/20 0.46
TNNI3K Q59H18 1/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
MITF O75030 1/20 0.46
PAX8 Q06710 1/20 0.46
PDGFRA P16234 1/20 0.45
HIF1A Q16665 3/20 0.45
POLB P06746 2/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
MAPT P10636 1/20 0.44
FFAR1 O14842 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24941705 0.88 SMN1; SMN2 (0.56) SMN1; SMN2NPC1RAB9APOLBMEN1
SCHEMBL21295515 0.87 MCHR1 (0.59) SMN1; SMN2MCHR1KDRTNNI3KNPC1
SCHEMBL21305509 0.82 HIF1A (0.46) SMN1; SMN2MCHR1KDRTNNI3KNPC1
SCHEMBL31653053 0.82 HIF1A (0.46) SMN1; SMN2MCHR1KDRTNNI3KNPC1
SCHEMBL21295386 0.81 MCHR1 (0.57) MCHR1KDRRAB9APDGFRAHIF1A
SCHEMBL21295536 0.80 KDR (0.61) MCHR1KDRRAB9APDGFRAHIF1A
SCHEMBL29625931 0.79 MAPK1 (0.52) SMN1; SMN2KDRTNNI3KNPC1RAB9A
SCHEMBL23041997 0.79 MAPK1 (0.52) SMN1; SMN2KDRTNNI3KNPC1RAB9A
SCHEMBL21305523 0.79 SMN1; SMN2 (0.59) SMN1; SMN2NPC1RAB9APOLBMEN1
SCHEMBL21295346 0.78 MCHR1 (0.53) SMN1; SMN2MCHR1NPC1RAB9AMITF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2025-07-03 US disclosed
EP-3759088-B1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2023-01-25 EP disclosed
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2022-09-29 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
EP-3759088-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS Alzecure Pharma AB (SE) 2021-01-06 EP disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF SMN1; SMN2 649/4885MCHR1 321/4885GPR174 763/4885
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF SMN1; SMN2 649/4885MCHR1 321/4885GPR174 763/4885
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins NTRK2, BDNF, NGF SMN1; SMN2 619/4885MCHR1 317/4885GPR174 648/4885
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF SMN1; SMN2 619/4885MCHR1 317/4885GPR174 648/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.