SCHEMBL21295536

SCHEMBL21295536

COc1cc(NC(=O)Nc2ccccc2)ccc1Oc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 3/20 0.61
PDGFRA P16234 2/20 0.61
MCHR1 Q99705 2/20 0.60
MEN1 O00255 7/20 0.59
KMT2A Q03164 7/20 0.59
MAPT P10636 5/20 0.59
TP53 P04637 2/20 0.58
TSHR P16473 1/20 0.58
TTR P02766 1/20 0.58
CSF1R P07333 1/20 0.57
ALDH1A1 P00352 4/20 0.57
RAB9A P51151 2/20 0.57
KDM4E B2RXH2 2/20 0.57
HSD17B10 Q99714 2/20 0.57
HPGD P15428 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
RCE1 Q9Y256 1/20 0.57
LMNA P02545 1/20 0.56
HIF1A Q16665 1/20 0.56
RAF1 P04049 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21295339 0.94 TP53 (0.63) KDRPDGFRAMCHR1MEN1KMT2A
SCHEMBL21295375 0.93 TP53 (0.66) KDRPDGFRAMEN1KMT2AMAPT
SCHEMBL30743987 0.93 TP53 (0.66) KDRPDGFRAMEN1KMT2AMAPT
SCHEMBL8348684 0.91 MCHR1 (0.67) KDRPDGFRAMCHR1MEN1KMT2A
SCHEMBL8350552 0.90 KMT2A (0.72) MEN1KMT2AMAPTTP53ALDH1A1
SCHEMBL14384694 0.87 TTR (0.60) MCHR1MEN1KMT2AMAPTTTR
SCHEMBL21295515 0.85 MCHR1 (0.59) KDRPDGFRAMCHR1MEN1KMT2A
SCHEMBL21295333 0.85 CA2 (0.54) KDRPDGFRAMCHR1MEN1KMT2A
SCHEMBL30744007 0.85 CA2 (0.54) KDRPDGFRAMCHR1MEN1KMT2A
SCHEMBL21295386 0.84 MCHR1 (0.57) KDRPDGFRAMCHR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2025-07-03 US disclosed
CN-111819172-B Triazine derivatives for the treatment of neurotrophin related diseases 阿泽克制药公司 2024-02-06 CN disclosed
EP-3759088-B1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2023-01-25 EP disclosed
EP-3759088-B1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2023-01-25 EP disclosed
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2022-09-29 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
EP-3759088-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS Alzecure Pharma AB (SE) 2021-01-06 EP disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
CN-111819172-A Triazine derivatives for the treatment of neurotrophin-related disorders 阿泽克制药公司 2020-10-23 CN disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF KDR 950/4885PDGFRA 844/4885MCHR1 321/4885
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF KDR 950/4885PDGFRA 844/4885MCHR1 321/4885
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins NTRK2, BDNF, NGF KDR 734/4885PDGFRA 680/4885MCHR1 317/4885
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF KDR 734/4885PDGFRA 680/4885MCHR1 317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.