Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.46 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28487568 | 0.81 | HTR2C (0.45) | HTR2CDRD2HTR2AHTR2BGUSB | |
| SCHEMBL1065758 | 0.81 | HTR2C (0.77) | HTR2CDRD2HTR2AHTR2BTRPV6 | |
| SCHEMBL28487441 | 0.79 | SCN9A (0.47) | HTR2C | |
| SCHEMBL24040028 | 0.78 | AKR1C3 (0.47) | — | |
| SCHEMBL28413632 | 0.78 | AKR1C3 (0.47) | — | |
| SCHEMBL24040040 | 0.78 | AKR1C3 (0.47) | — | |
| SCHEMBL28487048 | 0.78 | SCN9A (0.46) | HTR2CDRD2HCRTR2GUSB | |
| SCHEMBL29042316 | 0.76 | SLC6A2 (0.55) | CHRM3 | |
| SCHEMBL29042338 | 0.76 | SLC6A2 (0.55) | CHRM3 | |
| SCHEMBL22816107 | 0.76 | HTR2C (0.66) | HTR2CDRD2HTR2AHTR2BUSP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3759098-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | Genentech, Inc. (US) | 2021-01-06 | — | — | EP | disclosed |
| WO-2019165290-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | GENENTECH, INC. (US) | 2019-08-29 | — | — | WO | disclosed |