Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21296782 | 0.80 | PDE4B (0.41) | USP30 | |
| SCHEMBL9909930 | 0.78 | NR1H2 (0.39) | USP30HDAC1HSP90AA1HSP90AB1ELANE | |
| SCHEMBL21296771 | 0.76 | MAP2K4 (0.39) | USP30HSP90AA1HSP90AB1NR1H2 | |
| SCHEMBL1864917 | 0.76 | FAAH (0.40) | USP30SMARCA2SMARCA4PBRM1BCHE | |
| SCHEMBL4237117 | 0.75 | SMARCA2 (0.40) | SMARCA2SMARCA4PBRM1BCHEHDAC1 | |
| SCHEMBL23610579 | 0.74 | ELANE (0.41) | HDAC1ABCB1ELANE | |
| SCHEMBL4951116 | 0.72 | KDM5A (0.40) | USP30ELANENR1H2RORCFAAH | |
| SCHEMBL22165763 | 0.72 | ROCK2 (0.48) | SMARCA2SMARCA4PBRM1BCHEHDAC1 | |
| SCHEMBL693588 | 0.71 | FAAH (0.41) | USP30BCHEABCB1ELANEMAPK1 | |
| SCHEMBL23610578 | 0.71 | KMT2A (0.54) | HDAC1ABCB1ELANEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530181-B2 | IL-6 inhibitors and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210206718-A1 | IL-6 INHIBITORS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2021-07-08 | — | — | US | disclosed |
| WO-2019165158-A1 | IL-6 INHIBITORS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530181-B2 | IL-6 inhibitors and methods of treatment | IL6, IL6ST, IL2 | USP30 1921/4885SMARCA2 4325/4885SMARCA4 4345/4885 |
| US-20210206718-A1 | IL-6 INHIBITORS AND METHODS OF TREATMENT | IL6, IL6ST, IL2 | USP30 1921/4885SMARCA2 4325/4885SMARCA4 4345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.