Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21296781 | 0.88 | MAPT (0.47) | CNR1NPC1SMN1; SMN2MAPTALOX15 | |
| SCHEMBL21296840 | 0.84 | ACP1 (0.42) | JAK2JAK3 | |
| SCHEMBL21296774 | 0.78 | MAPT (0.46) | JAK2JAK3MAPTALDH1A1TDP1 | |
| SCHEMBL21296771 | 0.76 | MAP2K4 (0.39) | NPC1SMN1; SMN2MAPTRAB9AMEN1 | |
| SCHEMBL21296842 | 0.75 | BRAF (0.49) | NPC1SMN1; SMN2MAPTRAB9AKDM4E | |
| SCHEMBL21296800 | 0.75 | CNR1 (0.43) | CNR1ALDH1A1 | |
| SCHEMBL23610573 | 0.73 | SCN3A (0.44) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL23610577 | 0.73 | HSD17B1 (0.47) | ALOX15TSHRMEN1POLBKMT2A | |
| SCHEMBL21296776 | 0.70 | KMT2A (0.53) | NPC1SMN1; SMN2MAPTALDH1A1RAB9A | |
| SCHEMBL23610572 | 0.70 | KMT2A (0.54) | NPC1SMN1; SMN2MAPTALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165158-A1 | IL-6 INHIBITORS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-08-29 | — | — | WO | disclosed |